Document Type



Life Sciences | Molecular Biology | Structural Biology


Using MRS imaging and singular value decomposition (SVD), Manganas et al. (Science 318, 980,2007) reported a nuclear magnetic resonance diagnostic for neural progenitor cells. Characteristics of MRS experiments are known to be problematic for SVD-based methods. Absent detection using alternate methods of spectrum analysis or controls to quantify the false discovery rate, little significance can be attached to their result.


Published in final edited form as:
Science. 2008 August 1; 321(5889): 640. doi:10.1126/science.1153058.