Life Sciences | Medicine and Health Sciences
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N-nitroso compounds. Using these biocolloids, turnover rates were measured within 2 min. Inhibitor IC50 values for ketoconazole (KET) and 4-methylpyrazole (4-MEP) were estimated.
Bajrami, Besnik; Krishnan, Sadagopan; and Rusling, James F., "Microsome Biocolloids for Rapid Drug Metabolism and Inhibition Assessment by LC-MS" (2008). Articles - Research. 169.