Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N-nitroso compounds. Using these biocolloids, turnover rates were measured within 2 min. Inhibitor IC50 values for ketoconazole (KET) and 4-methylpyrazole (4-MEP) were estimated.

Comments

Drug Metab Lett. Author manuscript; available in PMC 2012 October 17. Published in final edited form as: Drug Metab Lett. 2008 August; 2(3): 158–162. PMCID: PMC3473178 NIHMSID: NIHMS412752

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