Date of Completion

Spring 5-1-2016

Project Advisor(s)

Akiko Nishiyama; Dennis Wright; Daniel Schwartz

University Scholar Major

Pharmacy Studies

Disciplines

Cellular and Molecular Physiology | Medicinal Chemistry and Pharmaceutics | Molecular and Cellular Neuroscience | Nervous System Diseases

Abstract

Gliomas, a type of brain tumor, can be difficult to treat and have a poor survival rate. One pathway that leads to glioma formation is excessive signaling by platelet derived growth factors (PDGF) through PDGF receptor α (PDGFRα). Through this research, I found that novel compounds that downregulate PDGFRα decrease proliferation of Oli-neu cells, an oligodendrocyte precursor cell model, and identified signaling pathways through which these compounds may exert their effect. Further investigation may identify targets for development of glioma treatments.